Special MoLife Research Seminar by:
Prof. Dr. Imre Tóth, University of Debrecen, Department of Inorganic and Analytical Chemistry, Debrecen, Hungary
Title of the talk:
Metal complexes in medical imaging: contribution of coordination chemistry to efficiency and safety
Abstract:
Almost all medical imaging modalities (i.e. MRI, PET, SPECT, and Fluorescence Imaging) and radiotherapy use metal complexes. An estimate of multimillion examinations makes this a multibillion dollar business worldwide. Although the physics behind the different modalities are fairly different, there are many similarities in the chemistry. The complexes should be thermodynamically very stable, kinetically inert, fast-forming, water soluble, effective, selective etc. and non-toxic. These often conflicting requirements need careful ligand design (both linear and macrocyclic ones) and detailed physicochemical characterisation of the agents in vitro before any biological experiments.1 We are working mainly with Gd(III)-based MRI contrast agents (commercial and potentially new)2-4 and with Mn(II)-complexes5 as the most promising family to replace GdCAs being alone in the market. I will summarise the basic principles, strategies and some new results6 together with newly patented Mn(II)- agents7 already attracting some industrial interest.
References:
1 Brücher E, Tircsó G, Baranyai Z, Kovács Z, and Sherry A D, The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging; ed. A. E. Merbach, L. Helm and E. Tóth., John Wiley & Sons, Chichester, Second Edition, 2013, 4, 157-208.
2 Baranyai Z, Brucher E, Uggeri F, Maiocchi A, Toth I, Andrasi M, Gaspar A, Zekany L, Aime S, The Role of Equilibrium and Kinetic Properties in the Dissociation of Gd[DTPA-bis(methylamide)] (Omniscan) at near to Physiological Conditions; CHEMISTRY-A EUROPEAN JOURNAL 21:(12) pp. 4789-4799 (2015)
3 Rodriguez-Rodriguez A, Esteban-Gomez D, Tripier R, Tircso G, Garda Z, Toth I, de Blas A, Rodriguez-Blas T, Platas-Iglesias C, Lanthanide(III) Complexes with a Reinforced Cyclam Ligand Show Unprecedented Kinetic Inertness; JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136:(52) pp. 17954-17957 (2014)
4Tircsó G, Regueiro-Figueroa M, Nagy V, Garda Z, Garai T, Kálmán F K, Esteban-Gómez D, Tóth É, Platas-Iglesias C, Approaching the Kinetic Inertness of Macrocyclic Gadolinium(III)-Based MRI Contrast Agents with Highly Rigid Open-Chain Derivatives; CHEMISTRY-A EUROPEAN JOURNAL 22:(3) pp. 896-901 (2016)
5Garda Z, Forgács A, Do Q N, Kálmán F K, Timári S, Baranyai Z, Tei L, Tóth I, Kovács Z, Tircsó G, Physico-chemical properties of Mn(II) complexes formed with cis- and trans-DO2A: Thermodynamic, electrochemical and kinetic studies; JOURNAL OF INORGANIC BIOCHEMISTRY 163: pp. 206-213. (2016)
6Nagy G, Szikra D, Trencsényi G, Fekete A, Garai I, Giani A M, Negri R, Masciocchi N, Maiocchi A, Uggeri F, Tóth I, Aime S, Giovenzana G B., Baranyai Z, AAZTA: An Ideal Chelating Agent for the Development of 44Sc PET Imaging Agents; ANGEWANDTE CHEMIE INT. EDITION, pp. 2150–2154 (2017)
7 Baranyai Z, Garda Z, Kalman F K, Krusper L, Tircso G, Toth I, Ghiani S, Maiocchi A, Ethylenediaminetetraacetic acid bis(amide) derivatives and their respective complexes with Mn(II) ion for use as MRI contrast agent. Patent application, WO2016135234, (2016) Acknowledgement: This work was supported by Hungarian Scientific Research Fund (K-109029 and K- 120224) and the EU and co-financed by the European Regional Development Fund under the project GINOP- 2.3.2-15-2016-00008.
