Prof. Dr. Mathias Winterhalter

Professor of Biophysics

School of Science

Constructor University Bremen gGmbH
Campus Ring 6 / 28759 Bremen / Germany

Phone number

+49 421 200-3248

Fax number

+49 421 200-3249

Email Address

mwinterhalter@constructor.university

Office

Research II, Room 87

Website

http://winterhalter.user.jacobs-university.de/

Biophysics

Research Interests

Selective permeability is a key feature of biological membranes, and is controlled by the lipid membrane and membrane proteins, which form channels that allow specific molecules to pass through. Our team develops methods to quantify transport across membranes and membrane channels. In particular, we are trying to understand the pathway of antibiotics on a molecular level. At Constructor University, we collaborate closely with the teams lead by Prof. Ullrich Kleinekathöfer, Prof. Werner Nau, and Prof R. Wagner, as well as with our collaboration partner at the Fraunhofer Institute IME in Hamburg.

Selected Publications

The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

JM Pagès, CE James, M Winterhalter

Nature Reviews Microbiology 6 (12), 893-903

Towards the sustainable discovery and development of new antibiotics

M Miethke, M Pieroni, T Weber, M Brönstrup, P Hammann, L Halby, ...

Nature Reviews Chemistry 5 (10), 726-749

Designed to penetrate: time-resolved interaction of single antibiotic molecules with bacterial pores

EM Nestorovich, C Danelon, M Winterhalter, SM Bezrukov

Proceedings of the National Academy of Sciences 99 (15), 9789-9794

Protein encapsulation in liposomes: efficiency depends on interactions between protein and phospholipid bilayer.

JP Colletier, B Chaize, M Winterhalter, D Fournier

BMC biotechnology 2, 1-8

Reconstitution of channel proteins in (polymerized) ABA triblock copolymer membranes

W Meier, C Nardin, M Winterhalter

Angewandte Chemie International Edition 39 (24), 4599-4602

Nanoengineered polymer capsules: tools for detection, controlled delivery, and site‐specific manipulation

GB Sukhorukov, AL Rogach, B Zebli, T Liedl, AG Skirtach, K Köhler, ...

Small 1 (2), 194-200

Amphiphilic block copolymer nanocontainers as bioreactors

C Nardin, J Widmer, M Winterhalter, W Meier

The European Physical Journal E 4, 403-410

Nanoreactors based on (polymerized) ABA-triblock copolymer vesicles

C Nardin, S Thoeni, J Widmer, M Winterhalter, W Meier

Chemical Communications, 1433-1434

Effect of surface charge on the curvature elasticity of membranes

M Winterhalter, W Helfrich

The Journal of Physical Chemistry 92 (24), 6865-6867

Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria

J Vergalli, IV Bodrenko, M Masi, L Moynié, S Acosta-Gutiérrez, ...

Nature Reviews Microbiology 18 (3), 164-176

Multifunctionalized polymer microcapsules: novel tools for biological and pharmacological applications

GB Sukhorukov, AL Rogach, M Garstka, S Springer, WJ Parak, ...

Small 3 (6), 944-955

Stealth® liposomes: from theory to product

B Cˇeh, M Winterhalter, PM Frederik, JJ Vallner, DD Lasic

Advanced Drug Delivery Reviews 24 (2-3), 165-177

The temperature dependence of lipid membrane permeability, its quantized nature, and the influence of anesthetics

A Blicher, K Wodzinska, M Fidorra, M Winterhalter, T Heimburg

Biophysical journal 96 (11), 4581-4591

Relationship between the growth regime of polyelectrolyte multilayers and the polyanion/polycation complexation enthalpy

N Laugel, C Betscha, M Winterhalter, JC Voegel, P Schaaf, V Ball

The journal of physical chemistry B 110 (39), 19443-19449

Transport of maltodextrins through maltoporin: a single-channel study

L Kullman, M Winterhalter, SM Bezrukov

Biophysical journal 82 (2), 803-812

Structural basis for nutrient acquisition by dominant members of the human gut microbiota

AJ Glenwright, KR Pothula, SP Bhamidimarri, DS Chorev, A Baslé, ...

Nature 541 (7637), 407-411

Giant free-standing ABA triblock copolymer membranes

C Nardin, M Winterhalter, W Meier

Langmuir 16 (20), 7708-7712

Bending elasticity of electrically charged bilayers: coupled monolayers, neutral surfaces, and balancing stresses

M Winterhalter, W Helfrich

The journal of physical chemistry 96 (1), 327-330

Nanoreactors from polymer-stabilized liposomes

A Graff, M Winterhalter, W Meier

Langmuir 17 (3), 919-923

Large-conductance transmembrane porin made from DNA origami

K Göpfrich, CY Li, M Ricci, SP Bhamidimarri, J Yoo, B Gyenes, ...

ACS nano 10 (9), 8207-8214

Publications on Scopus

Conformational flexibility driving charge-selective substrate translocation across a bacterial transporter

Vikraman, D. Majumdar, B.B. Sk, S. Weichbrodt, C. Fertig, N. Winterhalter, M. Mondal, J. Mahendran, K.R.

Chemical Science 2024

Fosfomycin Uptake in Escherichia coli Is Mediated by the Outer-Membrane Porins OmpF, OmpC, and LamB

Bianchi, M. Winterhalter, M. Harbig, T.A. Hörömpöli, D. Ghai, I. Nieselt, K. Brötz-Oesterhelt, H. Mayer, C. Borisova-Mayer, M.

ACS Infectious Diseases 2024 10 (1) pp. 127-137

Metallacarborane Cluster Anions of the Cobalt Bisdicarbollide-Type as Chaotropic Carriers for Transmembrane and Intracellular Delivery of Cationic Peptides

Chen, Y. Folgar-Cameán, Y. Montenegro, J. Nau, W.M. Barba-Bon, A. Grüner, B. Winterhalter, M. Aksoyoglu, M.A. Pangeni, S. Ashjari, M. Brix, K. Salluce, G.

Journal of the American Chemical Society 2023 145 (24) pp. 13089-13098

Influence of Membrane Asymmetry on OmpF Insertion, Orientation and Function

Donoghue, A. Winterhalter, M. Gutsmann, T.

Membranes 2023 13 (5)

How the physical properties of bacterial porins match environmental conditions

Milenkovic, S. Wang, J. Acosta-Gutierrez, S. Winterhalter, M. Ceccarelli, M. Bodrenko, I.V.

Physical Chemistry Chemical Physics 2023 25 (18) pp. 12712-12722

Conformational Dynamics of Loop L3 in OmpF: Implications toward Antibiotic Translocation and Voltage Gating

Acharya, A. Ghai, I. Piselli, C. Prajapati, J.D. Benz, R. Winterhalter, M. Kleinekathöfer, U.

Journal of Chemical Information and Modeling 2023 63 (3) pp. 910-927

TolC-AcrA complex formation monitored by time dependent single-channel electrophysiology

Bodrenko, I.V. Zewdie, T.A. Wang, J. Paul, E. Witt, S. Winterhalter, M.

Biochimie 2023 205 pp. 102-109

Editorial: Nanopore Electrochemistry

Long, Y.-T. Wanunu, M. Winterhalter, M.

Chemistry - An Asian Journal 2023 18 (3)

Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane

Masi, M. Vergalli, J. Ghai, I. Barba-Bon, A. Schembri, T. Nau, W.M. Lafitte, D. Winterhalter, M. Pagès, J.-M.

Communications Biology 2022 5 (1)

Identification of Single Amino Acid Chiral and Positional Isomers Using an Electrostatically Asymmetric Nanopore

Wang, J. Prajapati, J.D. Gao, F. Ying, Y.-L. Kleinekathöfer, U. Winterhalter, M. Long, Y.-T.

Journal of the American Chemical Society 2022 144 (33) pp. 15072-15078

The cryo-EM structure of the S-layer deinoxanthin-binding complex of Deinococcus radiodurans informs properties of its environmental interactions

Farci, D. Haniewicz, P. de Sanctis, D. Iesu, L. Kereïche, S. Winterhalter, M. Piano, D.

Journal of Biological Chemistry 2022 298 (6)

Silicon Nitride‐Based Micro‐Apertures Coated with Parylene for the Investigation of Pore Proteins Fused in Free‐Standing Lipid Bilayers

Ahmed, T. Bafna, J.A. Hemmler, R. Gall, K. Wagner, R. Winterhalter, M. Vellekoop, M.J. van den Driesche, S.

Membranes 2022 12 (3)

Total synthesis and mechanism of action of the antibiotic armeniaspirol A

Arisetti, N. Bafna, J.A. Hinkelmann, B. Eckel, K. Sieber, S.A. Müller, P.P. Herrmann, J. Müller, R. Winterhalter, M. Steinem, C. Brönstrup, M. Fuchs, H.L.S. Coetzee, J. Orozco, M. Ruppelt, D. Bauer, A. Heimann, D. Kuhnert, E. Bhamidimarri, S.P.

Chemical Science 2021 12 (48) pp. 16023-16034

The C2 entity of chitosugars is crucial in molecular selectivity of the Vibrio campbellii chitoporin

Suginta, W. Sanram, S. Aunkham, A. Winterhalter, M. Schulte, A.

Journal of Biological Chemistry 2021 297 (6)

Antibiotic uptake through porins located in the outer membrane of Gram-negative bacteria

Winterhalter, M.

Expert Opinion on Drug Delivery 2021 18 (4) pp. 449-457

Changes in Salt Concentration Modify the Translocation of Neutral Molecules through a ΔCymA Nanopore in a Non-monotonic Manner

Prajapati, J.D. Pangeni, S. Aksoyoglu, M.A. Winterhalter, M. Kleinekathöfer, U.

ACS Nano 2021

A general approach to protein folding using thermostable exoshells

Sadeghi, S. Deshpande, S. Vallerinteavide Mavelli, G. Aksoyoglu, A. Bafna, J. Winterhalter, M. Kini, R.M. Lane, D.P. Drum, C.L.

Nature Communications 2021 12 (1)

Structural analysis of the architecture and in situ localization of the main S-layer complex in Deinococcus radiodurans

Farci, D. Kereïche, S. Pangeni, S. Haniewicz, P. Bodrenko, I.V. Ceccarelli, M. Winterhalter, M. Piano, D.

Structure 2021 29 (11) pp. 1279-1285.e3

Towards the sustainable discovery and development of new antibiotics

Miethke, M. Bode, H.B. Moreira, R. Li, Y. Luzhetskyy, A. Medema, M.H. Pernodet, J.-L. Stadler, M. Tormo, J.R. Genilloud, O. Truman, A.W. Pieroni, M. Weissman, K.J. Takano, E. Sabatini, S. Stegmann, E. Brötz-Oesterhelt, H. Wohlleben, W. Seemann, M. Empting, M. Hirsch, A.K.H. Loretz, B. Weber, T. Lehr, C.-M. Titz, A. Herrmann, J. Jaeger, T. Alt, S. Hesterkamp, T. Winterhalter, M. Schiefer, A. Pfarr, K. Hoerauf, A. Brönstrup, M. Graz, H. Graz, M. Lindvall, M. Ramurthy, S. Karlén, A. van Dongen, M. Petkovic, H. Keller, A. Peyrane, F. Donadio, S. Hammann, P. Fraisse, L. Piddock, L.J.V. Gilbert, I.H. Moser, H.E. Müller, R. Halby, L. Arimondo, P.B. Glaser, P. Aigle, B.

Nature Reviews Chemistry 2021 5 (10) pp. 726-749

Detection and quantification of small concentrations of moxifloxacin using surface-enhanced Raman spectroscopy in a Kretschmann configuration

Mohaghegh, F. Mazaheri Tehrani, A. Rana, D. Winterhalter, M. Materny, A.

Journal of Raman Spectroscopy 2021 52 (9) pp. 1617-1629

How to Enter a Bacterium: Bacterial Porins and the Permeation of Antibiotics

Prajapati, J.D. Kleinekathöfer, U. Winterhalter, M.

Chemical Reviews 2021 121 (9) pp. 5158-5192

Large-Peptide Permeation Through a Membrane Channel: Understanding Protamine Translocation Through CymA from Klebsiella Oxytoca**

Pangeni, S. Prajapati, J.D. Bafna, J. Nilam, M. Nau, W.M. Kleinekathöfer, U. Winterhalter, M.

Angewandte Chemie - International Edition 2021 60 (15) pp. 8089-8094

Rapid fabrication of teflon apertures by controlled high voltage pulses for formation of free standing planar lipid bilayer membrane

Ozturk, Y. Ebrahimi, A. Norouz Dizaji, A. Kaygusuz, O. Bafna, J.A. Winterhalter, M. Cankaya, G. Darcan, C. Dogan Guzel, F.

Biomedical Microdevices 2021 23 (1)

Towards understanding single-channel characteristics of OccK8 purified from Pseudomonas aeruginosa

Dogan Guzel, F. Pletzer, D. Norouz Dizaji, A. Al-Nahas, K. Bajrai, M. Winterhalter, M.

European Biophysics Journal 2021 50 (1) pp. 87-98

Serial femtosecond crystallography on in vivo-grown crystals drives elucidation of mosquitocidal Cyt1Aa bioactivation cascade

Tetreau, G. Grünewald, T.A. Beaudouin, J. Snigireva, I. Fernandez-Luna, M.T. Burt, A. Park, H.-W. Signor, L. Bafna, J.A. Sadir, R. Fenel, D. Banneville, A.-S. Boeri-Erba, E. Bacia, M. Zala, N. Laporte, F. Després, L. Weik, M. Boutet, S. Rosenthal, M. Coquelle, N. Burghammer, M. Andreeva, E.A. Cascio, D. Sawaya, M.R. Winterhalter, M. Gratton, E. Gutsche, I. Federici, B. Pellequer, J.-L. Sauter, N.K. Colletier, J.-P. Brewster, A.S. Hunter, M.S. Sierra, R.G. Teulon, J.-M. Young, I.D. Burke, N.

Nature Communications 2020 11 (1)

The challenge of intracellular antibiotic accumulation, a function of fluoroquinolone influx versus bacterial efflux

Vergalli, J. Ruggerone, P. Pagès, J.-M. Atzori, A. Pajovic, J. Dumont, E. Malloci, G. Masi, M. Vargiu, A.V. Winterhalter, M. Réfrégiers, M.

Communications Biology 2020 3 (1)

Dynamic interaction of fluoroquinolones with magnesium ions monitored using bacterial outer membrane nanopores

Wang, J. Prajapati, J.D. Kleinekathöfer, U. Winterhalter, M.

Chemical Science 2020 11 (38) pp. 10344-10353

The Beauty of Asymmetric Membranes: Reconstitution of the Outer Membrane of Gram-Negative Bacteria

Paulowski, L. Donoghue, A. Nehls, C. Groth, S. Koistinen, M. Hagge, S.O. Böhling, A. Winterhalter, M. Gutsmann, T.

Frontiers in Cell and Developmental Biology 2020 8

Kanamycin Uptake into Escherichia coli Is Facilitated by OmpF and OmpC Porin Channels Located in the Outer Membrane

Bafna, J.A. Sans-Serramitjana, E. Acosta-Gutiérrez, S. Bodrenko, I.V. Hörömpöli, D. Berscheid, A. Brötz-Oesterhelt, H. Winterhalter, M. Ceccarelli, M.

ACS Infectious Diseases 2020 6 (7) pp. 1855-1865

Computational Modeling of Ion Transport in Bulk and through a Nanopore Using the Drude Polarizable Force Field

Prajapati, J.D. Mele, C. Aksoyoglu, M.A. Winterhalter, M. Kleinekathöfer, U.

Journal of Chemical Information and Modeling 2020 60 (6) pp. 3188-3203

Electroosmosis Dominates Electrophoresis of Antibiotic Transport Across the Outer Membrane Porin F

Bafna, J.A. Pangeni, S. Winterhalter, M. Aksoyoglu, M.A.

Biophysical Journal 2020 118 (11) pp. 2844-2852

Rapid lipid bilayer membrane formation on Parylene coated apertures to perform ion channel analyses

Ahmed, T. van den Driesche, S. Bafna, J.A. Oellers, M. Hemmler, R. Gall, K. Wagner, R. Winterhalter, M. Vellekoop, M.J.

Biomedical Microdevices 2020 22 (2)

Electrophysiological Characterization of Transport Across Outer-Membrane Channels from Gram-Negative Bacteria in Presence of Lipopolysaccharides

Wang, J. Terrasse, R. Bafna, J.A. Benier, L. Winterhalter, M.

Angewandte Chemie - International Edition 2020 59 (22) pp. 8517-8521

Structural insights into the main S-layer unit of Deinococcus radiodurans reveal a massive protein complex with porin-like features

Farci, D. Piano, D. Aksoyoglu, M.A. Farci, S.F. Bafna, J.A. Bodrenko, I. Ceccarelli, M. Kirkpatrick, J. Winterhalter, M. Kereïche, S.

Journal of Biological Chemistry 2020 295 (13) pp. 4224-4236

Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria

Vergalli, J. Winterhalter, M. Pagès, J.-M. Bodrenko, I.V. Masi, M. Moynié, L. Acosta-Gutiérrez, S. Naismith, J.H. Davin-Regli, A. Ceccarelli, M. van den Berg, B.

Nature Reviews Microbiology 2020 18 (3) pp. 164-176

The Structural Basis for Low Conductance in the Membrane Protein VDAC upon β-NADH Binding and Voltage Gating

Böhm, R. Amodeo, G.F. Murlidaran, S. Chavali, S. Wagner, G. Winterhalter, M. Brannigan, G. Hiller, S.

Structure 2020 28 (2) pp. 206-214.e4

Rapid formation of lipid bilayer membranes in parylene-C coated chips by pseudo-painting of air bubble for the fusion and detection of outer membrane vehicles (OMVs)

Ahmed, T. Bafna, J.A. van den Driesche, S. Oellers, M. Hemmler, R. Gall, K. Wagner, R. Winterhalter, M. Vellekoop, M.J.

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 2019 pp. 360-361

Mechanistic aspects of maltotriose-conjugate translocation to the Gram-negative bacteria cytoplasm

Dumont, E. Winterhalter, M. Réfrégiers, M. Pagès, J.-M. Vergalli, J. Pajovic, J. Bhamidimarri, S.P. Morante, K. Wang, J. Lubriks, D. Suna, E. Stavenger, R.A.

Life Science Alliance 2019 2 (1)

Outer Membrane Porins

Masi, M. Winterhalter, M. Pagès, J.-M.

Subcellular Biochemistry 2019 92 pp. 79-123

Parylene-C coated micro-apertures with painted synthetic lipid bilayer membranes for the investigation of outer-membrane-vesicle fusion

Ahmed, T. Den Driesche, S.V. Arun Bafna, J. Oellers, M. Hemmler, R. Gall, K. Wagner, R. Winterhalter, M. Vellekoop, M.J.

Proceedings of IEEE Sensors 2019 2019-October

Manipulation of charge distribution in the arginine and glutamate clusters of the OmpG pore alters sugar specificity and ion selectivity

Schmitt, C. Bafna, J.A. Schmid, B. Klingl, S. Baier, S. Hemmis, B. Wagner, R. Winterhalter, M. Voll, L.M.

Biochimica et Biophysica Acta - Biomembranes 2019 1861 (10)

Breaching the Barrier: Quantifying Antibiotic Permeability across Gram-negative Bacterial Membranes

Cama, J. Henney, A.M. Winterhalter, M.

Journal of Molecular Biology 2019 431 (18) pp. 3531-3546

Identification and characterization of approved drugs and drug-like compounds as covalent Escherichia coli clpp inhibitors

Sassetti, E. Cruz, C.D. Tammela, P. Winterhalter, M. Augustyns, K. Gribbon, P. Windshügel, B.

International Journal of Molecular Sciences 2019 20 (11)

Small-Molecule Permeation across Membrane Channels: Chemical Modification to Quantify Transport across OmpF

Wang, J. Bafna, J.A. Bhamidimarri, S.P. Winterhalter, M.

Angewandte Chemie - International Edition 2019 58 (14) pp. 4737-4741

Effects of H-bonds on sugar binding to chitoporin from Vibrio harveyi

Chumjan, W. Winterhalter, M. Suginta, W.

Biochimica et Biophysica Acta - Biomembranes 2019 1861 (3) pp. 610-618

A Multidisciplinary Approach toward Identification of Antibiotic Scaffolds for Acinetobacter baumannii

Bhamidimarri, S.P. Winterhalter, M. van den Berg, B. Zahn, M. Prajapati, J.D. Schleberger, C. Söderholm, S. Hoover, J. West, J. Kleinekathöfer, U. Bumann, D.

Structure 2019 27 (2) pp. 268-280.e6

α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease

Moreno-Cinos, C. Brötz-Oesterhelt, H. Tammela, P. Winterhalter, M. Gribbon, P. Windshügel, B. Augustyns, K. Sassetti, E. Salado, I.G. Witt, G. Benramdane, S. Reinhardt, L. Cruz, C.D. Joossens, J. Van Der Veken, P.

Journal of Medicinal Chemistry 2019 62 (2) pp. 774-797

Fosfomycin Permeation through the Outer Membrane Porin OmpF

Golla, V.K. Sans-Serramitjana, E. Pothula, K.R. Benier, L. Bafna, J.A. Winterhalter, M. Kleinekathöfer, U.

Biophysical Journal 2019 116 (2) pp. 258-269

Quantifying Permeation of Small Charged Molecules across Channels: Electrophysiology in Small Volumes

Wang, J. Benier, L. Winterhalter, M.

ACS Omega 2018 3 (12) pp. 17481-17486

Large-area highly stable on-chip lipid bilayers probed by AFM

Oellers, M. Ciacchi, L.C. Vellekoop, M.J. Van Den Driesche, S. Wei, G. Ahmed, T. Bhamidimarri, S.P. Hemmler, R. Gall, K. Winterhalter, M. Wagner, R.

22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 2018 4 pp. 2235-2238

A microfluidic actuator to purify outer membrane vesicles released by Gram-negative bacteria

Van Den Driesche, S. Vellekoop, M.J. Dobielewski, M. Oellers, M. Ahmed, T. Terrasse, R. Hemmler, R. Gall, K. Winterhalter, M. Wagner, R.

22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 2018 3 pp. 1417-1420

Getting Drugs into Gram-Negative Bacteria: Rational Rules for Permeation through General Porins

Acosta-Gutiérrez, S. Pagès, J.-M. Naismith, J.H. Van Den Berg, B. Page, M.G.P. Ceccarelli, M. Ferrara, L. Pathania, M. Masi, M. Wang, J. Bodrenko, I. Zahn, M. Winterhalter, M. Stavenger, R.A.

ACS Infectious Diseases 2018 4 (10) pp. 1487-1498

Getting Drugs through Small Pores: Exploiting the Porins Pathway in Pseudomonas aeruginosa

Samanta, S. Winterhalter, M. Van Den Berg, B. Ceccarelli, M. Bodrenko, I. Acosta-Gutiérrez, S. D'Agostino, T. Pathania, M. Ghai, I. Schleberger, C. Bumann, D. Wagner, R.

ACS Infectious Diseases 2018 4 (10) pp. 1519-1528

Translocation of small molecules through engineered outer-membrane channels from Gram-negative bacteria

Terrasse, R. Winterhalter, M.

European Physical Journal E 2018 41 (9)

The 2018 correlative microscopy techniques roadmap

Ando, T. Franck, C. Fritzsche, M. Gerritsen, H. Giepmans, B.N.G. Grunewald, K. Hofkens, J. Hoogenboom, J.P. Janssen, K.P.F. Kaufman, R. Klumpermann, J. Bhamidimarri, S.P. Kurniawan, N. Kusch, J. Liv, N. Parekh, V. Peckys, D.B. Rehfeldt, F. Reutens, D.C. Roeffaers, M.B.J. Salditt, T. Schaap, I.A.T. Brending, N. Schwarz, U.S. Verkade, P. Vogel, M.W. Wagner, R. Winterhalter, M. Yuan, H. Zifarelli, G. Collinson, L. De Jonge, N. Debroye, E. Eggeling, C.

Journal of Physics D: Applied Physics 2018 51 (44)

Ampicillin permeation across OmpF, the major outer-membrane channel in Escherichia coli

Ghai, I. Bajaj, H. Bafna, J.A. Hussein, H.A.E.D. Winterhalter, M. Wagner, R.

Journal of Biological Chemistry 2018 293 (18) pp. 7030-7037

Unusual Constriction Zones in the Major Porins OmpU and OmpT from Vibrio cholerae

Pathania, M. Acosta-Gutierrez, S. Bhamidimarri, S.P. Baslé, A. Winterhalter, M. Ceccarelli, M. van den Berg, B.

Structure 2018 26 (5) pp. 708-721.e4

Porin self-association enables cell-to-cell contact in Providencia stuartii floating communities

El-Khatib, M. Bolla, J.-M. Pagès, J.-M. Vivaudou, M. Weik, M. Winterhalter, M. Colletier, J.-P. Nasrallah, C. Lopes, J. Tran, Q.-T. Tetreau, G. Basbous, H. Fenel, D. Gallet, B. Lethier, M.

Proceedings of the National Academy of Sciences of the United States of America 2018 115 (10) pp. E2220-E2228

Enrofloxacin Permeation Pathways across the Porin OmpC

Prajapati, J.D. Solano, C.J.F. Winterhalter, M. Kleinekathöfer, U.

Journal of Physical Chemistry B 2018 122 (4) pp. 1417-1426

Probing transport of fosfomycin through substrate specific OprO and OprP from Pseudomonas aeruginosa

Citak, F. Ghai, I. Rosenkötter, F. Benier, L. Winterhalter, M. Wagner, R.

Biochemical and Biophysical Research Communications 2018 495 (1) pp. 1454-1460

Engineering Enhanced Pore Sizes Using FhuA Δ1-160 from E. coli Outer Membrane as Template

Liu, Z. Ghai, I. Winterhalter, M. Schwaneberg, U.

ACS Sensors 2017 2 (11) pp. 1619-1626

Porin flexibility in Providencia stuartii: cell-surface-exposed loops L5 and L7 are markers of Providencia porin OmpPst1

Tran, Q.-T. Maigre, L. D'Agostino, T. Ceccarelli, M. Winterhalter, M. Pagès, J.-M. Davin-Regli, A.

Research in Microbiology 2017 168 (8) pp. 685-699

Characterization of Ciprofloxacin Permeation Pathways across the Porin OmpC Using Metadynamics and a String Method

Prajapati, J.D. Fernández Solano, C.J. Winterhalter, M. Kleinekathöfer, U.

Journal of Chemical Theory and Computation 2017 13 (9) pp. 4553-4566

Peptide translocation across MOMP, the major outer membrane channel from Campylobacter jejuni

Dhanasekar, N.N. Aliouane, S. Winterhalter, M. Pagès, J.-M. Bolla, J.-M.

Biochemistry and Biophysics Reports 2017 11 pp. 79-83

Sensing Single Molecule Penetration into Nanopores: Pushing the Time Resolution to the Diffusion Limit

Bodrenko, I.V. Wang, J. Salis, S. Winterhalter, M. Ceccarelli, M.

ACS Sensors 2017 2 (8) pp. 1184-1190

Polydopamine Coating to Stabilize a Free-Standing Lipid Bilayer for Channel Sensing

Neveshkin, A. Citak, F. Ball, V. Winterhalter, M.

Langmuir 2017 33 (29) pp. 7256-7262

Bacterial Outer Membrane Porins as Electrostatic Nanosieves: Exploring Transport Rules of Small Polar Molecules

Bajaj, H. Acosta Gutierrez, S. Bodrenko, I. Malloci, G. Scorciapino, M.A. Winterhalter, M. Ceccarelli, M.

ACS Nano 2017 11 (6) pp. 5465-5473

Understanding Carbapenem Translocation through OccD3 (OpdP) of Pseudomonas aeruginosa

Soundararajan, G. Bhamidimarri, S.P. Winterhalter, M.

ACS Chemical Biology 2017 12 (6) pp. 1656-1664

Protein A Functionalized Polyelectrolyte Microcapsules as a Universal Platform for Enhanced Targeting of Cell Surface Receptors

Kolesnikova, T.A. Kiragosyan, G. Le, T.H.N. Springer, S. Winterhalter, M.

ACS Applied Materials and Interfaces 2017 9 (13) pp. 11506-11517

Single Residue Acts as Gate in OccK Channels

Pothula, K.R. Dhanasekar, N.N. Lamichhane, U. Younas, F. Pletzer, D. Benz, R. Winterhalter, M. Kleinekathöfer, U.

Journal of Physical Chemistry B 2017 121 (12) pp. 2614-2621

General Method to Determine the Flux of Charged Molecules through Nanopores Applied to β-Lactamase Inhibitors and OmpF

Ghai, I. Pira, A. Scorciapino, M.A. Bodrenko, I. Benier, L. Ceccarelli, M. Winterhalter, M. Wagner, R.

Journal of Physical Chemistry Letters 2017 8 (6) pp. 1295-1301

Probing transport of charged β-lactamase inhibitors through OmpC, a membrane channel from E. coli

Ghai, I. Winterhalter, M. Wagner, R.

Biochemical and Biophysical Research Communications 2017 484 (1) pp. 51-55

Structural basis for nutrient acquisition by dominant members of the human gut microbiota

Glenwright, A.J. Kleinekathöfer, U. Bolam, D.N. Van Den Berg, B. Pothula, K.R. Bhamidimarri, S.P. Chorev, D.S. Baslé, A. Firbank, S.J. Zheng, H. Robinson, C.V. Winterhalter, M.

Nature 2017 541 (7637) pp. 407-411

Mechanisms of intrinsic resistance and acquired susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients to temocillin, a revived antibiotic

Chalhoub, H. Denis, O. Winterhalter, M. Tulkens, P.M. Van Bambeke, F. Pletzer, D. Weingart, H. Braun, Y. Tunney, M.M. Elborn, J.S. Rodriguez-Villalobos, H. Plésiat, P. Kahl, B.C.

Scientific Reports 2017 7

Electronic laboratory notebooks in a public-private partnership

Vaas, L.A.I. Kohler, M. Witt, G. Windshügel, B. Bosin, A. Serra, G. Bruengger, A. Winterhalter, M. Gribbon, P. Levy-Petelinkar, C.J.

PeerJ Computer Science 2016 2016 (9)

Suginta, W. Winterhalter, M.

Biochimica et Biophysica Acta - Biomembranes 2016 1858 (12) pp. 3032-3040

Draft genome sequence of Dietzia maris DSM 43672, a Gram-positive bacterium of the mycolata group

Ganguly, S. Jimenez-Galisteo, G. Pletzer, D. Winterhalter, M. Benz, R. Viñas, M.

Genome Announcements 2016 4 (3)

MOMP from Campylobacter jejuni Is a Trimer of 18-Stranded β-Barrel Monomers with a Ca2 + Ion Bound at the Constriction Zone

Ferrara, L.G.M. Ceccarelli, M. Naismith, J.H. Wallat, G.D. Moynié, L. Dhanasekar, N.N. Aliouane, S. Acosta-Gutiérrez, S. Pagès, J.-M. Bolla, J.-M. Winterhalter, M.

Journal of Molecular Biology 2016 428 (22) pp. 4528-4543

Large-Conductance Transmembrane Porin Made from DNA Origami

Göpfrich, K. Keyser, U.F. Li, C.-Y. Ricci, M. Bhamidimarri, S.P. Yoo, J. Gyenes, B. Ohmann, A. Winterhalter, M. Aksimentiev, A.

ACS Nano 2016 10 (9) pp. 8207-8214

“To Catch or Not to Catch”: Microcapsule-Based Sandwich Assay for Detection of Proteins and Nucleic Acids

Verma, S.K. Amoah, A. Schellhaas, U. Winterhalter, M. Springer, S. Kolesnikova, T.A.

Advanced Functional Materials 2016 26 (33) pp. 6015-6024

Ion channels made from a single membrane-spanning DNA duplex

Göpfrich, K. Stulz, E. Aksimentiev, A. Keyser, U.F. Li, C.-Y. Mames, I. Bhamidimarri, S.P. Ricci, M. Yoo, J. Mames, A. Ohmann, A. Winterhalter, M.

Nano Letters 2016 16 (7) pp. 4665-4669

Molecular Basis of filtering carbapenems by porins from βlactam-resistant clinical strains of Escherichia coli

Bajaj, H. Scorciapino, M.A. Moynie, L. Page, M.G.P. Naismith, J.H. Ceccarelli, M. Winterhalter, M.

Journal of Biological Chemistry 2016 291 (6) pp. 2837-2847

Role of Electroosmosis in the Permeation of Neutral Molecules: CymA and Cyclodextrin as an Example

Bhamidimarri, S.P. Prajapati, J.D. Van Den Berg, B. Winterhalter, M. Kleinekathöfer, U.

Biophysical Journal 2016 110 (3) pp. 600-611

Structural Insights into Outer Membrane Permeability of Acinetobacter baumannii

Zahn, M. Bhamidimarri, S.P. Baslé, A. Winterhalter, M. Van Den Berg, B.

Structure 2016 24 (2) pp. 221-231

Hot start reverse transcriptase: an approach for improved real-time RT-PCR performance

Rutschke, N. Zimmermann, J. Möller, R. Klöck, G. Winterhalter, M. Leune, A.

Journal of Analytical Science and Technology 2015 6 (1)

Transport across the outer membrane porin of mycolic acid containing actinomycetales: Nocardia farcinica

Singh, P.R. Bajaj, H. Benz, R. Winterhalter, M. Mahendran, K.R.

Biochimica et Biophysica Acta - Biomembranes 2015 1848 (2) pp. 654-661

Polymer capsules and electroporation

Kolesnikova, T.A. Palankar, R. Winterhalter, M.

IFMBE Proceedings 2015 45 pp. 789-792

Toxins secreted by Bacillus isolated from lung adenocarcinomas favor the penetration of toxic substances

Merlos, A. Rodríguez, P. Bárcena-Uribarri, I. Winterhalter, M. Benz, R. Vinuesa, T. Moya, J.A. Viñas, M.

Frontiers in Microbiology 2015 6 (NOV)

Quantification of Fluoroquinolone Uptake through the Outer Membrane Channel OmpF of Escherichia coli

Cama, J. Bajaj, H. Pagliara, S. Maier, T. Braun, Y. Winterhalter, M. Keyser, U.F.

Journal of the American Chemical Society 2015 137 (43) pp. 13836-13843

Physical methods to quantify small antibiotic molecules uptake into Gram-negative bacteria

Winterhalter, M. Ceccarelli, M.

European Journal of Pharmaceutics and Biopharmaceutics 2015 95 pp. 63-67

Chitoporin from the marine bacterium vibrio harveyi: Probing the essential roles of Trp136 at the surface of the constriction zone

Chumjan, W. Winterhalter, M. Schulte, A. Benz, R. Suginta, W.

Journal of Biological Chemistry 2015 290 (31) pp. 19184-19196

Analysis of fast channel blockage: Revealing substrate binding in the microsecond range

Bodrenko, I. Bajaj, H. Ruggerone, P. Winterhalter, M. Ceccarelli, M.

Analyst 2015 140 (14) pp. 4820-4827

Antibiotic translocation through porins studied in planar lipid bilayers using parallel platforms

Weichbrodt, C. Bajaj, H. Baaken, G. Wang, J. Guinot, S. Kreir, M. Behrends, J.C. Winterhalter, M. Fertig, N.

Analyst 2015 140 (14) pp. 4874-4881

The location of coenzyme Q10 in phospholipid membranes made of POPE: a small-angle synchrotron X-ray diffraction study

Wollstein, C. Winterhalter, M. Funari, S.S.

European Biophysics Journal 2015 44 (5) pp. 373-381

Crystal structure of a COG4313 outer membrane channel

Van Den Berg, B. Bhamidimarri, S.P. Winterhalter, M.

Scientific Reports 2015 5

Pore forming activity of the potent RTX-toxin produced by pediatric pathogen Kingella kingae: Characterization and comparison to other RTX-family members

Bárcena-Uribarri, I. Benz, R. Winterhalter, M. Zakharian, E. Balashova, N.

Biochimica et Biophysica Acta - Biomembranes 2015 1848 (7) pp. 1536-1544

Outer-membrane translocation of bulky small molecules by passive diffusion

Van Den Berg, B. Bhamidimarri, S.P. Prajapati, J.D. Kleinekathöfer, U. Winterhalter, M.

Proceedings of the National Academy of Sciences of the United States of America 2015 112 (23) pp. E2991-E2999

Understanding Voltage Gating of Providencia stuartii Porins at Atomic Level

Song, W. Bajaj, H. Nasrallah, C. Jiang, H. Winterhalter, M. Colletier, J.-P. Xu, Y.

PLoS Computational Biology 2015 11 (5)

Halogenated dodecaborate clusters as agents to trigger release of liposomal contents

Awad, D. Fritz, J. Edwards, K. Gabel, D. Bartok, M. Mostaghimi, F. Schrader, I. Sudumbrekar, N. Schaffran, T. Jenne, C. Eriksson, J. Winterhalter, M.

ChemPlusChem 2015 80 (4) pp. 656-664

Robotic voltammetry with carbon nanotube-based sensors: A superb blend for convenient high-quality antimicrobial trace analysis

Theanponkrang, S. Suginta, W. Weingart, H. Winterhalter, M. Schulte, A.

International Journal of Nanomedicine 2015 10 pp. 859-868

Protein reconstitution into freestanding planar lipid membranes for electrophysiological characterization

Gutsmann, T. Heimburg, T. Keyser, U. Mahendran, K.R. Winterhalter, M.

Nature Protocols 2015 10 (1) pp. 188-198

Resource efficiency studies using a new operator training simulator for a Bioethanol plant

Hass, V.C. Kuntzsch, S. Schoop, K.-M. Winterhalter, M.

Chemical Engineering Transactions 2014 39 (Special Issue) pp. 541-546

Pharmacological aspects of release from microcapsules - From polymeric multilayers to lipid membranes

Wuytens, P. Parakhonskiy, B. Yashchenok, A. Winterhalter, M. Skirtach, A.

Current Opinion in Pharmacology 2014 18 pp. 129-140

Investigation of the energy demand of batch rectification using a new training simulator Untersuchung des Energiebedarfs der batch-Rektifikation durch einen neuen Trainingssimulator

Kuntzsch, S. Winterhalter, M. Hass, V.

Chemie-Ingenieur-Technik 2014 86 (5) pp. 714-724

Synthetic ion transporters: Pore formation in bilayers via coupled activity of non-spanning cobalt-cage amphiphiles

Lalgee, L.J. Grierson, L. Fairman, R.A. Jaggernauth, G.E. Schulte, A. Benz, R. Winterhalter, M.

Biochimica et Biophysica Acta - Biomembranes 2014 1838 (5) pp. 1247-1254

Lipid membranes in external electric fields: Kinetics of large pore formation causing rupture

Winterhalter, M.

Advances in Colloid and Interface Science 2014 208 pp. 121-128

Interaction of protamine with gram-negative bacteria membranes: Possible alternative mechanisms of internalization in Escherichia coli, Salmonella typhimurium and Pseudomonas aeruginosa

Pink, D.A. Hasan, F.M. Quinn, B.E. Winterhalter, M. Mohan, M. Gill, T.A.

Journal of Peptide Science 2014 20 (4) pp. 240-250

Polydopamine films from the forgotten Air/water interface

Ponzio, F. Payamyar, P. Schneider, A. Winterhalter, M. Bour, J. Addiego, F. Krafft, M.-P. Hemmerle, J. Ball, V.

Journal of Physical Chemistry Letters 2014 5 (19) pp. 3436-3440

Nanoplasmonically-induced defects in lipid membrane monitored by ion current: Transient nanopores versus membrane rupture

Palankar, R. Pinchasik, B.-E. Khlebtsov, B.N. Kolesnikova, T.A. Möhwald, H. Winterhalter, M. Skirtach, A.G.

Nano Letters 2014 14 (8) pp. 4273-4279

Porin involvement in cephalosporin and carbapenem resistance of Burkholderia pseudomallei

Aunkham, A. Schulte, A. Winterhalter, M. Suginta, W.

PLoS ONE 2014 9 (5)

TRANSLOCATION project: How to get good drugs into bad bugs

Stavenger, R.A. Winterhalter, M.

Science Translational Medicine 2014 6 (228)

Chemosensing ensembles for monitoring biomembrane transport in real time

Ghale, G. Lanctôt, A.G. Kreissl, H.T. Jacob, M.H. Weingart, H. Winterhalter, M. Nau, W.M.

Angewandte Chemie - International Edition 2014 53 (10) pp. 2762-2765

Differential detergent extraction of Mycobacterium marinum cell envelope proteins identifies an extensively modified threonine-rich outer membrane protein with channel activity

van der Woude, A.D. Luirink, J. Bitter, W. Houben, E.N.G. Mahendran, K.R. Ummels, R. Piersma, S.R. Pham, T.V. Jiménez, C.R. de Punder, K. van der Wel, N.N. Winterhalter, M.

Journal of Bacteriology 2013 195 (9) pp. 2050-2059

Peptide translocation through the mesoscopic channel: Binding kinetics at the single molecule level

Lamichhane, U. Islam, T. Prasad, S. Weingart, H. Mahendran, K.R. Winterhalter, M.

European Biophysics Journal 2013 42 (5) pp. 363-369

Chitoporin from Vibrio harveyi, a channel with exceptional sugar specificity

Suginta, W. Chumjan, W. Mahendran, K.R. Schulte, A. Winterhalter, M.

Journal of Biological Chemistry 2013 288 (16) pp. 11038-11046

Molecular Uptake of Chitooligosaccharides through Chitoporin from the Marine Bacterium Vibrio harveyi

Suginta, W. Chumjan, W. Mahendran, K.R. Janning, P. Schulte, A. Winterhalter, M.

PLoS ONE 2013 8 (1)

Polypeptide translocation through the mitochondrial TOM channel: Temperature-dependent rates at the single-molecule level

Mahendran, K.R. Lamichhane, U. Romero-Ruiz, M. Nussberger, S. Winterhalter, M.

Journal of Physical Chemistry Letters 2013 4 (1) pp. 78-82

Antibiotic uptake through membrane channels: Role of Providencia stuartii omppst1 porin in carbapenem resistance

Bajaj, H. Tran, Q.-T. Mahendran, K.R. Nasrallah, C. Colletier, J.-P. Davin-Regli, A. Bolla, J.-M. Pagès, J.-M. Winterhalter, M.

Biochemistry 2012 51 (51) pp. 10244-10249

Pulling peptides across nanochannels: Resolving peptide binding and translocation through the hetero-oligomeric channel from nocardia farcinica

Singh, P.R. Bárcena-Uribarri, I. Modi, N. Kleinekathöfer, U. Benz, R. Winterhalter, M. Mahendran, K.R.

ACS Nano 2012 6 (12) pp. 10699-10707

Towards the development of a training simulator for biorefineries

Hass, V.C. Kuntzsch, S. Gerlach, I. Kühn, K. Winterhalter, M.

Chemical Engineering Transactions 2012 29 pp. 247-252

Nanoaggregates of micropurified lipopolysaccharide identified using dynamic light scattering, zeta potential measurement, and TLR4 signaling activity

Hardy, E. Kamphuis, T. Japaridze, A. Wilschut, J.C. Winterhalter, M.

Analytical Biochemistry 2012 430 (2) pp. 203-213

Computational modeling of ion transport through nanopores

Modi, N. Winterhalter, M. Kleinekathöfer, U.

Nanoscale 2012 4 (20) pp. 6166-6180

Modulation of enrofloxacin binding in OmpF by Mg 2+ as revealed by the analysis of fast flickering single-porin current

Brauser, A. Schroeder, I. Cosentino, C. Moroni, A. Hansen, U.-P. Winterhalter, M.

Journal of General Physiology 2012 140 (1) pp. 69-82

Antibiotic permeation across the OmpF channel: Modulation of the affinity site in the presence of magnesium

Raj Singh, P. Ceccarelli, M. Lovelle, M. Winterhalter, M. Mahendran, K.R.

Journal of Physical Chemistry B 2012 116 (15) pp. 4433-4438

Protein translocation through Tom40: Kinetics of peptide release

Mahendran, K.R. Romero-Ruiz, M. Schlösinger, A. Winterhalter, M. Nussberger, S.

Biophysical Journal 2012 102 (1) pp. 39-47

Thermodynamic study of Cu 2+ binding to the DAHK and GHK peptides by isothermal titration calorimetry (ITC) with the weaker competitor glycine

Trapaidze, A. Hureau, C. Bal, W. Winterhalter, M. Faller, P.

Journal of Biological Inorganic Chemistry 2012 17 (1) pp. 37-47

Raman imaging and photodegradation study of phthalocyanine containing microcapsules and coated particles

Bratashov, D.N. Winterhalter, M. Möhwald, H. Skirtach, A.G. Masic, A. Yashchenok, A.M. Bedard, M.F. Inozemtseva, O.A. Gorin, D.A. Basova, T. Sievers, T.K. Sukhorukov, G.B.

Journal of Raman Spectroscopy 2011 42 (10) pp. 1901-1907

Probing the transport of ionic liquids in aqueous solution through nanopores

Modi, N. Singh, P.R. Mahendran, K.R. Schulz, R. Winterhalter, M. Kleinekathöfer, U.

Journal of Physical Chemistry Letters 2011 2 (18) pp. 2331-2336

Simple reconstitution of protein pores in nano lipid bilayers

Gornall, J.L. Mahendran, K.R. Pambos, O.J. Steinbock, L.J. Otto, O. Chimerel, C. Winterhalter, M. Keyser, U.F.

Nano Letters 2011 11 (8) pp. 3334-3340

Molecular analysis of antimicrobial agent translocation through the membrane porin BpsOmp38 from an ultraresistant Burkholderia pseudomallei strain

Suginta, W. Mahendran, K.R. Chumjan, W. Hajjar, E. Schulte, A. Winterhalter, M. Weingart, H.

Biochimica et Biophysica Acta - Biomembranes 2011 1808 (6) pp. 1552-1559

Generation of artificial channels by multimerization of β-strands from natural porin

Lolicato, M. Reina, S. Messina, A. Guarino, F. Winterhalter, M. Benz, R. Pinto, V.D.

Biological Chemistry 2011 392 (7) pp. 617-624

Interaction of cephalosporins with outer membrane channels of Escherichia coli. Revealing binding by fluorescence quenching and ion conductance fluctuations

Lovelle, M. MacH, T. Mahendran, K.R. Weingart, H. Winterhalter, M. Gameiro, P.

Physical Chemistry Chemical Physics 2011 13 (4) pp. 1521-1530

Permeation of antibiotics through Escherichia coli OmpF and OmpC porins: Screening for influx on a single-molecule level

Mahendran, K.R. Kreir, M. Weingart, H. Fertig, N. Winterhalter, M.

Journal of Biomolecular Screening 2010 15 (3) pp. 302-307

New developments in nanopore research - From fundamentals to applications

Albrecht, T. Edel, J.B. Winterhalter, M.

Journal of Physics Condensed Matter 2010 22 (45)

Permeation through nanochannels: Revealing fast kinetics

Mahendran, K.R. Singh, P.R. Arning, J. Stolte, S. Kleinekathöfer, U. Winterhalter, M.

Journal of Physics Condensed Matter 2010 22 (45)

Retrieval of a metabolite from cells with polyelectrolyte microcapsules

Studer, D. Palankar, R. Bédard, M. Winterhalter, M. Springer, S.

Small 2010 6 (21) pp. 2412-2419

Implication of porins in β-lactam resistance of Providencia stuartii

Tran, Q.-T. Mahendran, K.R. Hajjar, E. Ceccarelli, M. Davin-Regli, A. Winterhalter, M. Weingart, H. Pagès, J.-M.

Journal of Biological Chemistry 2010 285 (42) pp. 32273-32281

Toward screening for antibiotics with enhanced permeation properties through bacterial porins

Hajjar, E. Bessonov, A. Molitor, A. Kumar, A. Mahendran, K.R. Winterhalter, M. Pagès, J.-M. Ruggerone, P. Ceccarelli, M.

Biochemistry 2010 49 (32) pp. 6928-6935

Interactions of mitochondrial presequence peptides with the mitochondrial outer membrane preprotein translocase TOM

Romero-Ruiz, M. Mahendran, K.R. Eckert, R. Winterhalter, M. Nussberger, S.

Biophysical Journal 2010 99 (3) pp. 774-781

Comparing the temperature-dependent conductance of the two structurally similar E. coli porins OmpC and OmpF

Biró, I. Pezeshki, S. Weingart, H. Winterhalter, M. Kleinekathöfer, U.

Biophysical Journal 2010 98 (9) pp. 1830-1839

Molecular basis of enrofloxacin translocation through OmpF, an outer membrane channel of escherichia coli - When binding does not imply translocation

Mahendran, K.R. Winterhalter, M. Ceccarelli, M. Hajjar, E. MacH, T. Lovelle, M. Kumar, A. Sousa, I. Spiga, E. Weingart, H. Gameiro, P.

Journal of Physical Chemistry B 2010 114 (15) pp. 5170-5179

Unimolecular study of the interaction between the outer membrane protein OmpF from E. coli and an analogue of the HP(2-20) antimicrobial peptide

Apetrei, A. Asandei, A. Park, Y. Hahm, K.-S. Winterhalter, M. Luchian, T.

Journal of Bioenergetics and Biomembranes 2010 42 (2) pp. 173-180

Bridging timescales and length scales: From macroscopic flux to the molecular mechanism of antibiotic diffusion through porins

Hajjar, E. Mahendran, K.R. Kumar, A. Bessonov, A. Petrescu, M. Weingart, H. Ruggerone, P. Winterhalter, M. Ceccarelli, M.

Biophysical Journal 2010 98 (4) pp. 569-575

Interaction of N,N,N-trialkylammonioundecahydro-closo-dodecaborates with dipalmitoyl phosphatidylcholine liposomes

Schaffran, T. Li, J. Karlsson, G. Edwards, K. Winterhalter, M. Gabel, D.

Chemistry and Physics of Lipids 2010 163 (1) pp. 64-73

The temperature dependence of lipid membrane permeability, its quantized nature, and the influence of anesthetics

Blicher, A. Wodzinska, K. Fidorra, M. Winterhalter, M. Heimburg, T.

Biophysical Journal 2009 96 (11) pp. 4581-4591

Pyridinium lipids with the dodecaborate cluster as polar headgroup: Synthesis, characterization of the physical-chemical behavior, and toxicity in cell culture

Schaffran, T. Burghardt, A. Barnert, S. Peschka-Süss, R. Schubert, R. Winterhalter, M. Gabel, D.

Bioconjugate Chemistry 2009 20 (11) pp. 2190-2198

Understanding ion conductance on a molecular level: An all-atom modeling of the bacterial porin OmpF

Pezeshki, S. Chimerel, C. Bessonov, A.N. Winterhalter, M. Kleinekathöfer, U.

Biophysical Journal 2009 97 (7) pp. 1898-1906

Antibiotic translocation through membrane channels: Temperature-dependent ion current fluctuation for catching the fast events

Mahendran, K.R. Chimerel, C. MacH, T. Winterhalter, M.

European Biophysics Journal 2009 38 (8) pp. 1141-1145

Polyelectrolyte-coated unilamellar nanometer-sized magnetic liposomes

Da Silva Gomes, J.F.P. Rank, A. Kronenberger, A. Fritz, J. Winterhalter, M. Ramaye, Y.

Langmuir 2009 25 (12) pp. 6793-6799

How β-lactam antibiotics enter bacteria: A dialogue with the porins

James, C.E. Mahendran, K.R. Molitor, A. Bolla, J.-M. Bessonov, A.N. Winterhalter, M. Pagès, J.-M.

PLoS ONE 2009 4 (5)

Dodecaborate cluster lipids with variable headgroups for boron neutron capture therapy: Synthesis, physical-chemical properties and toxicity

Schaffran, T. Gabel, D. Lissel, F. Samatanga, B. Karlsson, G. Burghardt, A. Edwards, K. Winterhalter, M. Peschka-Süss, R. Schubert, R.

Journal of Organometallic Chemistry 2009 694 (11) pp. 1708-1712

Interaction of Na2B12H11SH with dimyristoyl phosphatidylcholine liposomes

Awad, D. Damian, L. Winterhalter, M. Karlsson, G. Edwards, K. Gabel, D.

Chemistry and Physics of Lipids 2009 157 (2) pp. 78-85

Fluorescence quenching as a tool to investigate quinolone antibiotic interactions with bacterial protein OmpF

Neves, P. Sousa, I. Winterhalter, M. Gameiro, P.

Journal of Membrane Biology 2009 227 (3) pp. 133-140

Chapter 2 Functionalized Liposomes

Palankar, R. Ramaye, Y. Fournier, D. Winterhalter, M.

Advances in Planar Lipid Bilayers and Liposomes 2008 7 pp. 39-58

Biophysical characterization of in- and efflux in gram-negative bacteria

Weingart, H. Petrescu, M. Winterhalter, M.

Current Drug Targets 2008 9 (9) pp. 789-796

The porin and the permeating antibiotic: A selective diffusion barrier in Gram-negative bacteria

Pagès, J.-M. James, C.E. Winterhalter, M.

Nature Reviews Microbiology 2008 6 (12) pp. 893-903

Transport at the nanoscale: Temperature dependence of ion conductance

Chimerel, C. Movileanu, L. Pezeshki, S. Winterhalter, M. Kleinekathöfer, U.

European Biophysics Journal 2008 38 (1) pp. 121-125

Facilitated permeation of antibiotics across membrane channels - Interaction of the quinolone moxifloxacin with the OmpF channel

Mach, T. Neves, P. Spiga, E. Weingart, H. Winterhalter, M. Ruggerone, P. Ceccarelli, M. Gameiro, P.

Journal of the American Chemical Society 2008 130 (40) pp. 13301-13309

Miniaturized planar lipid bilayer: Increased stability, low electric noise and fast fluid perfusion

MacH, T. Chimerel, C. Fritz, J. Fertig, N. Winterhalter, M. Fütterer, C.

Analytical and Bioanalytical Chemistry 2008 390 (3) pp. 841-846

Multifunctionalized polymer microcapsules: Novel tools for biological and pharmacological applications

Sukhorukov, G.B. Ramaye, Y. Palankar, R. Winterhalter, M. Rogach, A.L. Garstka, M. Springer, S. Parak, W.J. Muñoz-Javier, A. Kreft, O. Skirtach, A.G. Susha, A.S.

Small 2007 3 (6) pp. 944-955

The anionic boron cluster (B12H11SH)2- as a means to trigger release of liposome contents

Gabel, D. Awad, D. Schaffran, T. Radovan, D. Dǎrǎban, D. Damian, L. Winterhalter, M. Karlsson, G. Edwards, K.

ChemMedChem 2007 2 (1) pp. 51-53

Microstructured liposome array

Chaize, B. Winterhalter, M. Fournier, D. Nguyen, M. Ruysschaert, T. Le Berre, V. Trévisiol, E. Caminade, A.-M. Majoral, J.P. Pratviel, G. Meunier, B.

Bioconjugate Chemistry 2006 17 (1) pp. 245-247

Stabilization of liposomes through enzymatic polymerization of DNA

Ruysschaert, T. Paquereau, L. Winterhalter, M. Fournier, D.

Nano Letters 2006 6 (12) pp. 2755-2757

Interaction of zwitterionic penicillins with the OmpF channel facilitates their translocation

Danelon, C. Nestorovich, E.M. Winterhalter, M. Ceccarelli, M. Bezrukov, S.M.

Biophysical Journal 2006 90 (5) pp. 1617-1627

Composite nanocapsules: Lipid vesicles covered with several layers of crosslinked polyelectrolytes

Germain, M. Grube, S. Carriere, V. Richard-Foy, H. Winterhalter, M. Fournier, D.

Advanced Materials 2006 18 (21) pp. 2868-2871

Structural and thermodynamical properties of CuII amyloid-β16/28 complexes associated with Alzheimer's disease

Guilloreau, L. Damian, L. Coppel, Y. Mazarguil, H. Winterhalter, M. Faller, P.

Journal of Biological Inorganic Chemistry 2006 11 (8) pp. 1024-1038

Relationship between the growth regime of polyelectrolyte multilayers and the polyanion/polycation complexation enthalpy

Laugel, N. Betscha, C. Winterhalter, M. Voegel, J.C. Schaaf, P. Ball, V.

Journal of Physical Chemistry B 2006 110 (39) pp. 19443-19449

Stable polymethacrylate nanocapsules from ultraviolet light-induced template radical polymerization of unilamellar liposomes

Da Silva Gomes, J.F.P. Sonnen, A.F.-P. Kronenberger, A. Fritz, J. Coelho, M.A.N. Fournier, D. Fournier-Nöel, C. Mauzac, M. Winterhalter, M.

Langmuir 2006 22 (18) pp. 7755-7759

Docking of a Single Phage Lambda to its Membrane Receptor Maltoporin as a Time-resolved Event

Gurnev, P.A. Oppenheim, A.B. Winterhalter, M. Bezrukov, S.M.

Journal of Molecular Biology 2006 359 (5) pp. 1447-1455

A nanocompartment system (Synthosome) designed for biotechnological applications

Nallani, M. Benito, S. Onaca, O. Graff, A. Lindemann, M. Winterhalter, M. Meier, W. Schwaneberg, U.

Journal of Biotechnology 2006 123 (1) pp. 50-59

Stable air bubbles - Catch them if you can!

Winterhalter, M. Sonnen, A.F.-P.

Angewandte Chemie - International Edition 2006 45 (16) pp. 2500-2502

Interaction of bacteriophage lambda with its cell surface receptor: An in vitro study of binding of the viral tail protein gpJ to LamB (maltoporin)

Berkane, E. Orlik, F. Stegmeier, J.F. Charbit, A. Winterhalter, M. Benz, R.

Biochemistry 2006 45 (8) pp. 2708-2720

Protection of mammalian cell used in biosensors by coating with a polyelectrolyte shell

Germain, M. Balaguer, P. Nicolas, J.-C. Lopez, F. Esteve, J.-P. Sukhorukov, G.B. Winterhalter, M. Richard-Foy, H. Fournier, D.

Biosensors and Bioelectronics 2006 21 (8) pp. 1566-1573

Functional subconformations in protein folding: Evidence from single-channel experiments

Kullman, L. Gurnev, P.A. Winterhalter, M. Bezrukov, S.M.

Physical Review Letters 2006 96 (3)

Functional sub-conformations in protein folding: Evidence from single-channel experiments

Kullman, L. Winterhalter, M. Bezrukov, S.M.

AIP Conference Proceedings 2005 800 pp. 343-348

Reconstitution of General Diffusion Pores from Bacterial Outer Membranes

Danelon, C. Winterhalter, M.

Bacterial and Eukaryotic Porins: Structure, Function, Mechanism 2005 pp. 99-117

Liposome retention in size exclusion chromatography

Ruysschaert, T. Marque, A. Duteyrat, J.-L. Lesieur, S. Winterhalter, M. Fournier, D.

BMC Biotechnology 2005 5

Hybrid nanocapsules: Interactions of ABA block copolymers with liposomes

Ruysschaert, T. Sonnen, A.F.P. Haefele, T. Meier, W. Winterhalter, M. Fournier, D.

Journal of the American Chemical Society 2005 127 (17) pp. 6242-6247

Nanoengineered polymer capsules: Tools for detection, controlled delivery, and site-specific manipulation

Sukhorukov, G.B. Winterhalter, M. Parak, W.J. Rogach, A.L. Zebli, B. Liedl, T. Skirtach, A.G. Köhler, K. Antipov, A.A. Gaponik, N. Susha, A.S.

Small 2005 1 (2) pp. 194-200

Channel-Forming Membrane Proteins as Molecular Sensors

Danelon, C. Lindemann, M. Borin, C. Fournier, D. Winterhalter, M.

IEEE Transactions on Nanobioscience 2004 3 (1) pp. 46-48

Liposome-Based Nanocapsules

Ruysschaert, T. Germain, M. Gomes, J.F.P.D.S. Fournier, D. Sukhorukov, G.B. Meier, W. Winterhalter, M.

IEEE Transactions on Nanobioscience 2004 3 (1) pp. 49-55

Nanocapsules with Functionalized Surfaces and Walls

Coelho, M.A.N. Gliozzi, A. Möhwald, H. Perez, E. Sleytr, U. Vogel, H. Winterhalter, M.

IEEE Transactions on Nanobioscience 2004 3 (1) pp. 3-5

University Education

Technische Universität Berlin

September 1978 - August 1984

Field of study

Physics

Freie Universität Berlin

September 1978 - August 1984

Field of study

Physics

Work Experience

Professor of Biophysics at Paul Sabatier University - Toulouse III

Habilitation in Biophysics at University of Basel

Scientific Assistant for Biophysical Chemistry at University of Basel

Research Assistant at University of Wuerzburg

Postdoc at NIH/Washington

Lecturer at Fachhochschule der Deutschen Bundespost