Prof. Dr. Mathias Winterhalter

School of Science
Constructor University Bremen gGmbH
Campus Ring 6 / 28759 Bremen / Germany
Phone number
+49 421 200-3248
Fax number
+49 421 200-3249
Email Address
Research II, Room 87
Research Interests

Selective permeability is a key feature of biological membranes, and is controlled by the lipid membrane and membrane proteins, which form channels that allow specific molecules to pass through. Our team develops methods to quantify transport across membranes and membrane channels. In particular, we are trying to understand the pathway of antibiotics on a molecular level. At Constructor University, we collaborate closely with the teams lead by Prof. Ullrich Kleinekathöfer, Prof. Werner Nau, and Prof R. Wagner, as well as with our collaboration partner at the Fraunhofer Institute IME in Hamburg.

Selected Publications

The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

JM Pagès, CE James, M Winterhalter

Nature Reviews Microbiology 6 (12), 893-903

Towards the sustainable discovery and development of new antibiotics

M Miethke, M Pieroni, T Weber, M Brönstrup, P Hammann, L Halby, ...

Nature Reviews Chemistry 5 (10), 726-749

Designed to penetrate: time-resolved interaction of single antibiotic molecules with bacterial pores

EM Nestorovich, C Danelon, M Winterhalter, SM Bezrukov

Proceedings of the National Academy of Sciences 99 (15), 9789-9794

Protein encapsulation in liposomes: efficiency depends on interactions between protein and phospholipid bilayer.

JP Colletier, B Chaize, M Winterhalter, D Fournier

BMC biotechnology 2, 1-8

Reconstitution of channel proteins in (polymerized) ABA triblock copolymer membranes

W Meier, C Nardin, M Winterhalter

Angewandte Chemie International Edition 39 (24), 4599-4602

Nanoengineered polymer capsules: tools for detection, controlled delivery, and site‐specific manipulation

GB Sukhorukov, AL Rogach, B Zebli, T Liedl, AG Skirtach, K Köhler, ...

Small 1 (2), 194-200

Amphiphilic block copolymer nanocontainers as bioreactors

C Nardin, J Widmer, M Winterhalter, W Meier

The European Physical Journal E 4, 403-410

Nanoreactors based on (polymerized) ABA-triblock copolymer vesicles

C Nardin, S Thoeni, J Widmer, M Winterhalter, W Meier

Chemical Communications, 1433-1434

Effect of surface charge on the curvature elasticity of membranes

M Winterhalter, W Helfrich

The Journal of Physical Chemistry 92 (24), 6865-6867

Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria

J Vergalli, IV Bodrenko, M Masi, L Moynié, S Acosta-Gutiérrez, ...

Nature Reviews Microbiology 18 (3), 164-176

Multifunctionalized polymer microcapsules: novel tools for biological and pharmacological applications

GB Sukhorukov, AL Rogach, M Garstka, S Springer, WJ Parak, ...

Small 3 (6), 944-955

Stealth® liposomes: from theory to product

B Cˇeh, M Winterhalter, PM Frederik, JJ Vallner, DD Lasic

Advanced Drug Delivery Reviews 24 (2-3), 165-177

The temperature dependence of lipid membrane permeability, its quantized nature, and the influence of anesthetics

A Blicher, K Wodzinska, M Fidorra, M Winterhalter, T Heimburg

Biophysical journal 96 (11), 4581-4591

Relationship between the growth regime of polyelectrolyte multilayers and the polyanion/polycation complexation enthalpy

N Laugel, C Betscha, M Winterhalter, JC Voegel, P Schaaf, V Ball

The journal of physical chemistry B 110 (39), 19443-19449

Transport of maltodextrins through maltoporin: a single-channel study

L Kullman, M Winterhalter, SM Bezrukov

Biophysical journal 82 (2), 803-812

Structural basis for nutrient acquisition by dominant members of the human gut microbiota

AJ Glenwright, KR Pothula, SP Bhamidimarri, DS Chorev, A Baslé, ...

Nature 541 (7637), 407-411

Giant free-standing ABA triblock copolymer membranes

C Nardin, M Winterhalter, W Meier

Langmuir 16 (20), 7708-7712

Bending elasticity of electrically charged bilayers: coupled monolayers, neutral surfaces, and balancing stresses

M Winterhalter, W Helfrich

The journal of physical chemistry 96 (1), 327-330

Nanoreactors from polymer-stabilized liposomes

A Graff, M Winterhalter, W Meier

Langmuir 17 (3), 919-923

Large-conductance transmembrane porin made from DNA origami

K Göpfrich, CY Li, M Ricci, SP Bhamidimarri, J Yoo, B Gyenes, ...

ACS nano 10 (9), 8207-8214


University Education

Technische Universität Berlin

September 1978 - August 1984

Field of study



Freie Universität Berlin

September 1978 - August 1984

Field of study


Work Experience

Professor of Biophysics at Paul Sabatier University - Toulouse III

Habilitation in Biophysics at University of Basel

Scientific Assistant for Biophysical Chemistry at University of Basel

Research Assistant at University of Wuerzburg

Postdoc at NIH/Washington

Lecturer at Fachhochschule der Deutschen Bundespost